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The HOPE Agora on evidence-informed decision-making in healthcare management will look at different approaches to answer these questions. Scientific literature is an important source of information. However, decisions are also influenced by local data, stakeholders’ positions, cultural factors, etc. The conference participants will discuss the role of different types and sources of evidence. The point of view of researchers, policy-makers, managers and many other stakeholders will be considered. In increasingly complex health systems, the ability to use all types of available evidence to improve decision-making in healthcare is crucial to ensure that citizens are offered the best care possible.